Life Sciences Assignment Notes On Diagnosis Of Plasmodium Knowlesi - 1100 Words

Life Sciences Assignment: Notes On Diagnosis Of Plasmodium Knowlesi (Essay Sample) Content: Updates on Knowlesi malariaShort introductionGeographical distribution * Malaysia (P. falciparum and P. vivax decline, main cause - P. knowlesi) * Human infections: Malaysia, Thailand, Singapore, Philippines, Vietnam, Cambodia, Indonesia, Brunei, Myanmar, Nicobar and Andaman Islands of India * Transmission * Natural hosts are long-tailed and pig-tailed macaques * Banded leaf monkey * Dusk or later * Peak biting time of vectors * Anopheles leucosphyrus group * An. balabacensis balabacensis, An latens, An dirus, An hacker, An cracens * Subsistence farmers, timber camp workers, hunters, travelers, army personnelEpidemiology * Rapid development of parasitemia * Short erythrocytic cycle of 24hrs * Some asymptomatic, some fatal * Fever with chills, headache, myalgia, poor appetite, arthralgia, cough, abdominal pain, diarrhea * Severe: jaundice, acute kidney injury, hypotension, acute respiratory distress syndrome, metabolic acidosis * Dengue-malaria co-infection * Severe - 35000/uL * Molecular * P. knowlesi is probably older than other malarial parasites * Two-highly divergent subpopulations of knowlesi * From long-tailed and pig-tailed macaques * Potential third subpopulation, 50 yr isolate from peninsular Malaysia and Philippines * Parasites in macaque hosts havent been under malarial drugs * ...